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Diagnostic Challenge: When It’s Not ITP

Diagnostic Challenge: When It's Not ITP

A case highlighting the importance of a broad differential diagnosis when the platelet count is low and the steroids are not working.

Case Presentation

A 34-year-old man was referred with presumed immune thrombocytopenia after two weeks of steroids produced no response. A repeat film showed platelet clumping; the true count was normal.

Discussion

Pseudothrombocytopenia from EDTA-dependent agglutination is easy to miss and easy to confirm. Always look at the film before committing a patient to immunosuppression.

References

  1. Provan D, et al. Blood Adv. 2019.

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